The single-use Nucleo bioreactor a collaborative product by ATMI LifeSciences and Pierre Guerin

ATMI LifeSciences is a leader in single-use mixing, storage, and bioreactor technology, fluoropolymer-based products, and custom-engineered, flexible packaging solutions. The business's fundamental knowledge of polymers, specially selected resins, and its clean room manufacturing experience combine to help drive optimum performance in critical disposable process operations.

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The use of Integrity TK8 film, ATMI's 'universal' bioprocess polymer film, across the entire Integrity line of storage and transfer vessels, mixing vessels and bioreactor vessels, is an industry first in standardization and serves to reduce validation burden, allowing end-users to implement and scale up processing more quickly and more efficiently...

The single-use Nucleo bioreactor is the product of a collaborative development effort by ATMI LifeSciences (which contributed the mixing, sparging and film technologies), Pierre Guerin (which provided hardware system including the software and control systems) and Artelis SA (which furnished the cell culture, process development and application expertise).
Based on ATMI's Pad-Drive disposable mixing platform, the cube-shaped disposable containment vessel provides a closed, fully sterile enclosure that delivers the same functionality as a conventional stirred tank bioreactor.

 

ATMI LifeSciences had established recognized leadership in the area of highly-efficient technologies for cell culture development and manufacturing. The companies' innovations in process optimization, for human and veterinary vaccine, recombinant protein, stem cell and cell therapy applications, integrate perfectly with ATMI's vision and strategy. Through close collaboration with customers, the acquisition in 2010 of Artelis SA will serve to provide enabling technologies in cell culture technology to the biopharmaceutical sector, in addition to having the industry's most comprehensive single-use platform and technical support.
ATMI manufactures the BPVs in plants located in Bloomington, Minnesota and in Hoegaarden, Belgium and in. For further information on ATMI and their full line of products, visit website